Microwave-assisted efficient synthesis of 2-arylbenzo[b]furans and 2-ferrocenylbenzo[b]furans from readily prepared propargylic alcohols and 𝑜-iodophenols

Journal of Chemical Sciences

Liansheng Wu¹  Guosheng Huang1¹  Fen Liang¹  Xiaoyun Xu¹  Xiaokang Shi¹ 

[1] State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China$$

关键词: Benzo[b]furan;    𝑜-iodophenol;    propargylic alcohols;    microwave irradiation.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple, efficient and expeditious method for synthesis of 2-arylbenzo[b]furans and 2-ferrocenylbenzo[b]furans from readily prepared propargylic alcohols, 𝑜-iodophenols and silica gel with the catalyst of PdCl2(PPh3)2 (2 mol%)/CuI (2mol%) and microwave-promoted Sonogashira coupling/cyclization reaction is developed. The methodology can produce good to excellent yields. In addition, this method can also be completed in one-pot with iodobenzene, 2-methyl-3-butyn-2-ol and 2-iodo-4-methylphenol as reactants.

【 授权许可】

Unknown