Chemo-enzymatic synthesis of new resveratrol-related dimers containing the benzo[b]furan framework and evaluation of their radical scavenger activities

TETRAHEDRON

卷:71

Article

Beneventi, Elisa^1,2  Conte, Silvia^1,2  Cramarossa, Maria Rita¹  Riva, Sergio²  Forti, Luca¹ 

[1] Dipartimento Sci Vita, I-41125 Modena, Italy

[2] CNR, Ist Chim Riconoscimento Mol, I-20131 Milan, Italy

关键词: Resveratrol;    Laccase;    Biocatalysis;    Oxidation;    Benzo[b]furan;   

DOI  :  10.1016/j.tet.2014.11.012

来源: Elsevier

【 摘 要 】

The chemo-enzymatic synthesis and the evaluation of radical scavenger performance of resveratrol-related dimers with antioxidative power have been investigated. The dimeric compounds, containing the benzo[b]furan framework, were prepared via an oxidative dimerization catalyzed by a laccase from Trametes versicolor, followed by a treatment with the organic oxidant DDQ This methodology can be useful for the synthesis of various 2,3-diarylbenzo[b]furans derivates, a class of compound that exhibits a wide range of biological activities. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free