An expeditious green synthesis of Schiff bases and azetidinones derivatised with 1,2,4-triazoles

Journal of Chemical Sciences

Ravindra R Kamble1¹  Bharathi V Badami¹  Tegginamath Gireesh¹  Tasneem Taj¹ 

[1] PG Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India$$

关键词: 1;    2;    4-Triazole;    Schiff base;    Mg(ClO4)2;    azetidinone;    solvent-free;    drug score;    MIC.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An efficient green approach to the synthesis of Schiff bases (11-21) of 1-amino-2-aryl-3-oxo-1,2,4-triazoles (1-3) have been reported under Mg(ClO4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield the azetidinones (22-32) with excellent yields. The synthesized compounds were evaluated for the extent of penetration into biological membranes ($clogP$), drug-likeliness and finally drug score was calculated and also screened for antitubercular and antimicrobial activities.

【 授权许可】

Unknown