期刊论文详细信息
Journal of Chemical Sciences | |
An expeditious green synthesis of Schiff bases and azetidinones derivatised with 1,2,4-triazoles | |
Ravindra R Kamble11  Bharathi V Badami1  Tegginamath Gireesh1  Tasneem Taj1  | |
[1] PG Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India$$ | |
关键词: 1; 2; 4-Triazole; Schiff base; Mg(ClO4)2; azetidinone; solvent-free; drug score; MIC.; | |
DOI : | |
来源: Indian Academy of Sciences | |
【 摘 要 】
An efficient green approach to the synthesis of Schiff bases (11-21) of 1-amino-2-aryl-3-oxo-1,2,4-triazoles (1-3) have been reported under Mg(ClO4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield the azetidinones (22-32) with excellent yields. The synthesized compounds were evaluated for the extent of penetration into biological membranes ($clogP$), drug-likeliness and finally drug score was calculated and also screened for antitubercular and antimicrobial activities.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040508279ZK.pdf | 187KB | download |