Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives

Molecules

Hakan Bektaş¹  Nesrin Karaali¹  Deniz Şahin¹  Ahmet Demirbaş¹  Şengül Alpay Karaoglu¹ 

[1] ¹Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey ²Department of Biology, Rize University, 53100 Rize, Turkey

关键词: 1;    2;    4-Triazole;    triazolo[3;    4-b][1;    3]benzoxazole;    primary amine;    Schiff base;    Mannich base;   

DOI  :  10.3390/molecules15042427

来源: mdpi

【 摘 要 】

Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.