Synthesis of new series of N-3-[-{2-(substituted phenyl-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine}-carbamyl]-propyl-2-aminothiazole and their biological importance

Journal of Chemical Sciences

Pushkal Samadhiya1¹  Santosh K Srivastava¹  Savitri D Srivastava¹  Ritu Sharma¹ 

[1] Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H S Gour University (A Central University), Sagar, India 470 003$$

关键词: Synthesis;    aminothiazole;    thiazolidinone;    antimicrobial;    antitubercular.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Synthesis of new series of N-3-[-{2-(substituted phenyl-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine}-carbamyl]-propyl-2-aminothiazole, 5(a-s) have been developed. The cycloaddition reaction of thioglycolic acid with N-{3-(substituted benzylidine-carbamyl)-propyl}-2-aminothiazole, 3(a-s) in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N1-3-[-{2-(substituted phenyl-4-oxo-1,3-thiazolidine}-carbamyl]-propyl-2-aminothiazole 4(a-s). The latter product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa undergoes Knoevenagel reaction to yield 5(a-s). The structure of compounds 1, 2, 3(a-s), 4(a-s) and 5(a-s) were confirmed by IR, 1H NMR, 13C NMR, FAB mass and chemical analysis. All final compounds were screened for their antimicrobial activity against some selected bacteria and fungi and antituberculosis study against M. tuberculosis, gave acceptable activity.

【 授权许可】

Unknown