A versatile and an efficient synthesis of 5-substituted-1𝐻-tetrazoles

Journal of Chemical Sciences

Madhusudana Reddy Muthukur Bhoje Gowd¹  Mohamed Afzal Pasha1¹ 

[1] Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore 560 001, India$$

关键词: Tetrazoles;    ZrOCl2·8 H2O;    DMF;    arylnitriles;    sodium azide.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple, efficient and a versatile method for the synthesis of 5-substituted-1𝐻-tetrazoles by a [3+2]-cycloaddition reaction of arylnitriles with sodium azide in DMF using ZrOCl2·8 H2O as catalyst has been developed. The reactions work well at 100°C and give the desired products in excellent yield. The examples studied include arylnitriles having electron donating as well as electron releasing groups on the arene nucleus.

【 授权许可】

Unknown