An asymmetric route to 2,3-epoxy-syn-1,4-cyclohexane diol derivatives using ring closing metathesis (RCM)

Journal of Chemical Sciences

Soumitra Maity¹  Subrata Ghosh1¹ 

[1] Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032$$

关键词: Asymmetric synthesis;    epoxides;    metathesis;    Michael addition;    natural products.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An asymmetric route for the synthesis of highly functionalized 2,3-epoxy-syn-1,4-cyclohexane diol derivatives present in some polyketide natural products has been developed. The key step involves RCM of an appropriately constructed 1,7-dienol derived from D-mannitol to cyclohexane-1,4-diol followed by its stereoselective epoxidation.

【 授权许可】

Unknown