Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes of phenyl-(4,5,9,14-tetraaza-benzo[𝑏]triphenylen-1,1-𝑦𝑙)-methanone

Journal of Chemical Sciences

Li-Feng Tan1 2¹  Xue-Jiao Chen¹  Xi-Ling Liang¹  Jian-Liang Shen² 

[1] College of Chemistry, Xiangtan University, Xiangtan 411105, P.R. China$$;Key Lab of Environment-friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, P.R. China$$

关键词: Ruthenium(II) complex;    DNA-binding;    photocleavage.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A novel polypyridyl ligand phenyl-(4,5,9,14-tetraaza-benzo[𝑏]triphenylen-1,1-𝑦𝑙)-methanone (PTBM) and its complexes [Ru(phen)2(PTBM)]2+ (1) (phen = 1,10-phenanthroline) and [Ru(bpy)2 (PTBM)]2+ (2) (bpy = 2,2'-bipyridine) have been synthesized and characterized by elemental analysis, mass spectroscopy, and 1H NMR. The DNA-binding properties of the two complexes were investigated by spectroscopic and viscosity measurements. The results indicate that both complexes bind to DNA via an intercalative mode and the DNA-binding affinity of complex 1 is greater than that of complex 2. When irradiated at 365 nm, complex 1 was found to be a more-effective DNA-cleaving agent than complex 2.

【 授权许可】

Unknown