Synthesis and antimicrobial activity of some novel thienopyrimidines and triazolothienopyrimidines

Journal of Chemical Sciences

Imtiyaz Ahmed M Khazi1¹  Nitinkumar S Shetty¹  Ravi S Lamani¹ 

[1] Department of Chemistry, Karnatak University, Dharwad 580 003$$

关键词: Thienopyrimidine;    triazolothienopyrimidine;    Gewald reaction;    antibacterial activity;    antifungal activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.

【 授权许可】

Unknown