Phytochemical screening and pharmacological activities of Ulmus campestris bark extracts

Oriental Pharmacy and Experimental Medicine

Hania Boudaoud-Ouahmed¹  Djebbar Atmani¹  Sid-Ali Tiab¹  Keltoum Ziane¹  Nabil Saidani¹  Mehdi Gherrou¹ 

[1] Université de Bejaia$$

关键词: Ulmus campestris;   

DOI  :  10.1007/s13596-015-0209-3

学科分类：药学

来源: Springer

【 摘 要 】

Ulmus campestris (Ulmaceae) is a medicinal plant traditionally used to treat various ailments, including inflammatory diseases. In order to establish pharmacological properties of Ulmus campestris bark extracts obtained with a selective extraction procedure, several studies were performed. Results showed strong scavenging activity of extracts against DPPH (IC₅₀ = 03.90 μg/ml), hydrogen peroxide (IC₅₀ = 71.05 μg/ml), hydroxyl (IC₅₀ = 40.13 μg/ml), hypochlorous acid (IC₅₀ < 100 μg/ml) and ABTS^•+ (IC₅₀ = 12.16 μg/ml) radicals. Moreover, U. Campestris extracts inhibited lipid peroxidation (52.60 ± 0.37 %) and xanthine oxidase activity (IC₅₀ = 285.25 μg/ml) effectively. The crude extract of U. campestris extract (400 mg/kg) exhibited a significant effect (50.60 %) on carrageenan-induced inflammation, acetic acid-induced writhing (33.68 %) and on tail immersion (73.00 %) tests. The extract was also effective on brewer’s yeast-induced fever. Obtained results may well explain the use of U. campestris in folk medicine, especially in the treatment of pain, gout and inflammatory diseases.

【 授权许可】

Unknown