Phytochemical screening and pharmacological activities of Ulmus campestris bark extracts

Hania Boudaoud-Ouahmed; Sid-Ali Tiab; Nabil Saidani; Mehdi Gherrou; Keltoum Ziane; Djebbar Atmani

doi:10.1007/s13596-015-0209-3

Oriental Pharmacy and Experimental Medicine

December 2015, Volume 15, Issue 4, pp 353–363

Phytochemical screening and pharmacological activities of Ulmus campestris bark extracts

Authors
Authors and affiliations

Hania Boudaoud-OuahmedEmail author
Sid-Ali Tiab
Nabil Saidani
Mehdi Gherrou
Keltoum Ziane
Djebbar Atmani

Research Article

First Online:: 02 November 2015

Received:: 09 April 2015
Accepted:: 12 October 2015

DOI: 10.1007/s13596-015-0209-3

Cite this article as:: Boudaoud-Ouahmed, H., Tiab, SA., Saidani, N. et al. Orient Pharm Exp Med (2015) 15: 353. doi:10.1007/s13596-015-0209-3

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Abstract

Ulmus campestris (Ulmaceae) is a medicinal plant traditionally used to treat various ailments, including inflammatory diseases. In order to establish pharmacological properties of Ulmus campestris bark extracts obtained with a selective extraction procedure, several studies were performed. Results showed strong scavenging activity of extracts against DPPH (IC₅₀ = 03.90 μg/ml), hydrogen peroxide (IC₅₀ = 71.05 μg/ml), hydroxyl (IC₅₀ = 40.13 μg/ml), hypochlorous acid (IC₅₀ < 100 μg/ml) and ABTS^•+ (IC₅₀ = 12.16 μg/ml) radicals. Moreover, U. Campestris extracts inhibited lipid peroxidation (52.60 ± 0.37 %) and xanthine oxidase activity (IC₅₀ = 285.25 μg/ml) effectively. The crude extract of U. campestris extract (400 mg/kg) exhibited a significant effect (50.60 %) on carrageenan-induced inflammation, acetic acid-induced writhing (33.68 %) and on tail immersion (73.00 %) tests. The extract was also effective on brewer’s yeast-induced fever. Obtained results may well explain the use of U. campestris in folk medicine, especially in the treatment of pain, gout and inflammatory diseases.

Keywords

Antioxidant Anti-inflammatory Anti-nociceptive Ulmus campestris

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Authors and Affiliations

Hania Boudaoud-Ouahmed
- 1
Email author
Sid-Ali Tiab
- 1
Nabil Saidani
- 1
Mehdi Gherrou
- 1
Keltoum Ziane
- 1
Djebbar Atmani
- 1

1.Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la VieUniversité de BejaiaBejaiaAlgeria

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Phytochemical screening and pharmacological activities of Ulmus campestris bark extracts

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