Effects of waterborne selenium exposure on the antioxidant and immunological activity in the goldfish, Carassius auratus

Molecular & Cellular Toxicology

Cheol Young Choi¹  Young Jae Choi¹  Mi Seon Park²  Gyung-Suk Kil¹  Hyun Suk Shin¹  Na Na Kim¹ 

[1] Korea Maritime and Ocean University$$;National Fisheries Research & Development Institute$$

关键词: Triiodothyronine (T3);   

DOI  :  10.1007/s13273-013-0045-9

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Selenium (Se) is an essential element that has relevant roles in growth, immunity, and the protection of cell membranes in organisms under normal conditions. The aim of this study was to test the antioxidant and immune functions of goldfish Carassius auratus after Se treatment. At the end of the experiment, levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and immune functions (immunoglobulin M protein and plasma lysozyme, thyroxine, and triiodothyronine) were significantly higher in goldfish exposed to 1 and 2 mg/L of Se than those exposed to 0.5 and 3 mg/L doses. In addition, plasma glutathione, H₂O₂, and lipid peroxidation levels were significantly lower in the 1 and 2 mg/L treatment group than 0.5 and 3 mg/L treatment group. These results indicated that 1 and 2 mg/L of Se enhance antioxidant defense and immune system function under aquarium conditions.

【 授权许可】

Unknown