The importance of IgG4 in the predictive model of thyroiditis

Endocrinology, Diabetes & Metabolism Case Reports

article

Milena S Pandrc¹  Stanko Petrović¹  Vanja Kostovski¹  Marijana Petrović¹  Miloš Zarić¹ 

[1] Militar Medical Academy

关键词: Adult;    Male;    White;    Serbia;    Pancreas;    Thyroid;    Thyroid;    Thyroxine (T4);    Triiodothyronine (T3);    TSH;    IgG4-related systemic disease;    Thyroiditis;    Hashimoto's disease;    Pancreatitis;    Weight loss;    Abdominal pain;    Biopsy;    Immunohistochemistry;    C-reactive protein;    Immunoglobulin G4;    Haemoglobin;    Lactate dehydrogenase;    Thyroid function;    FT4;    Total T3;    TSH;    Protein electrophoresis;    Ultrasound scan;    Thyroid antibodies;    Corticosteroids;    Radiology/Rheumatology;    New disease or syndrome: presentations/diagnosis/management;    August;    2015;   

DOI  :  10.1530/EDM-15-0038

学科分类：血液学

来源: Bioscientifica Ltd.

【 摘 要 】

Immunoglobulin (Ig)G4-related sclerosing disease (IgG4-RSD) is a new disease entity first proposed with regard toautoimmune pancreatitis. A 67-year-old male patient was examined because of weight loss and an abdominal pain. Based onthe clinical characteristics, laboratory parameters and ultrasound features, we identified the diagnosis of the IgG4-relatedsystemic disease (IgG4-RSD), that was confirmed by the histopathological analysis after the biopsy of the head of pancreas.After confirmation, we started with the corticosteroid therapy with a good clinical, biochemical and morphological response.During the previous therapy, the disturbance of glucoregulation appeared, so we had to change the modality of treatment.We decided to add Azathioprine to the therapy in a dose of 150 mg/day. We achieved a stable phase of the disease with IgG4.37 g/l and IgG4 0.179 g/l, and with no side effects from the therapy.

【 授权许可】

CC BY-NC-ND