Toxicity evaluation of inorganic nanoparticles: considerations and challenges

Molecular & Cellular Toxicology

Jong Kwon Lee³  Soo-Jin Choi¹  Jayoung Jeong³  Jin-Ho Choy² 

[1] Seoul Women’s University$$;Ewha Womans University$$;KFDA$$

关键词: Absorption mechanism;   

DOI  :  10.1007/s13273-013-0026-z

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Toxicity evaluation of inorganic nanoparticles in cell lines and in whole animals has been extensively explored in recent years. However, conflicting results have been reported regarding size-dependent toxicity and biokinetics in vitro and in vivo, and thus, basic questions regarding whether nanoparticles, ranged from 1 to 100 nm in size, are comparatively more toxic than larger-sized particles remain unanswered. This may be closely associated with changes in physicochemical properties of nanoparticles in biological fluids. Understanding in vivo physiological barriers, biological fates, and absorption mechanism of nanoparticles upon exposure routes will be useful to predict their toxicity potential. This review will highlight the critical points to be considered in order to evaluate the toxicity of inorganic nanoparticles, and discuss the issues and challenges emerging in the field of nanotoxicology.

【 授权许可】

Unknown