Toxicity evaluation of inorganic nanoparticles: considerations and challenges

Soo-Jin Choi; Jong Kwon Lee; Jayoung Jeong; Jin-Ho Choy

doi:10.1007/s13273-013-0026-z

Molecular & Cellular Toxicology

September 2013, Volume 9, Issue 3, pp 205–210

Toxicity evaluation of inorganic nanoparticles: considerations and challenges

Authors
Authors and affiliations

Soo-Jin ChoiEmail author
Jong Kwon Lee
Jayoung Jeong
Jin-Ho ChoyEmail author

Review Paper

First Online:: 03 October 2013

Received:: 28 August 2013
Accepted:: 29 August 2013

DOI: 10.1007/s13273-013-0026-z

Cite this article as:: Choi, SJ., Lee, J.K., Jeong, J. et al. Mol. Cell. Toxicol. (2013) 9: 205. doi:10.1007/s13273-013-0026-z

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Abstract

Toxicity evaluation of inorganic nanoparticles in cell lines and in whole animals has been extensively explored in recent years. However, conflicting results have been reported regarding size-dependent toxicity and biokinetics in vitro and in vivo, and thus, basic questions regarding whether nanoparticles, ranged from 1 to 100 nm in size, are comparatively more toxic than larger-sized particles remain unanswered. This may be closely associated with changes in physicochemical properties of nanoparticles in biological fluids. Understanding in vivo physiological barriers, biological fates, and absorption mechanism of nanoparticles upon exposure routes will be useful to predict their toxicity potential. This review will highlight the critical points to be considered in order to evaluate the toxicity of inorganic nanoparticles, and discuss the issues and challenges emerging in the field of nanotoxicology.

Keywords

Inorganic nanoparticles Toxicity Physicochemical property Physiological barriers Absorption mechanism

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Authors and Affiliations

Soo-Jin Choi
- 1
Email author
Jong Kwon Lee
- 2
Jayoung Jeong
- 2
Jin-Ho Choy
- 3
Email author

1.Department of Food Science and TechnologySeoul Women’s UniversitySeoulKorea
2.Toxicological Research Division, National Institute of Food & Drug Safety EvaluationKFDAChungchungbuk-doKorea
3.Center for Intelligent Nano-Bio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nano Science (Ewha Global Top 5 program-2011)Ewha Womans UniversitySeoulKorea

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Toxicity evaluation of inorganic nanoparticles: considerations and challenges

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