The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea: The ARIRANG study

Molecular & Cellular Toxicology

Byung-Su Yoo¹  Aeyong Eom²  Jang-Young Kim¹  Jong-Ku Park¹  Kyung-Hoon Choe¹  Sang-Baek Koh¹  Jin Ha Yoon¹  Seung-Hwan Lee¹  Young Jin Youn¹  Junghan Yoon¹  Joong Kyung Sung¹  Min-Soo Ahn³ 

[1] Yonsei University$$;Mokpo National University$$;Pusan National University Hospital$$

关键词: Carotid artery;   

DOI  :  10.1007/s13273-011-0005-1

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 g/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=�?0.27), body mass index (r=�?0.21), systolic blood pressure (r=�?0.11), diastolic blood pressure (r=�?0.10), triglyceride (r=�?0.30), LDL-cholesterol (r=�?0.02), glucose (r=�?0.16), insulin (r=�?0.17), homeostasis assessment-insulin resistance (r=�?0.23) and C-reactive protein (r=�?0.11), and correlated positively with HDL cholesterol (r=0.30) (all P<0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R²=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.

【 授权许可】

Unknown