Subacute Toxicity Assessment of Water Disinfection Byproducts on Zebrafish

Pathology & Oncology Research

Ivett Zsákovics³  László Sujbert⁴  Renáta Kis³  Árpád Hegyi²  Ferenc Baska²  Zsolt Csenki²  Béla Urbányi²  Ryan Gustafson¹  Béla Szende⁴  Gergely Rácz⁴  Róbert Kovács² 

[1] University of North Carolina at Chapel Hill$$;Szent István University$$;3D HISTECH Kft$$;Semmelweis University Budapest$$

关键词: Water disinfection byproducts;   

DOI  :  10.1007/s12253-011-9479-3

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Disinfection of raw water is essential to the production of drinking water. However, by-products of disinfection may exert toxic effects. The potential toxic effects of two of these compounds, 4-ethylbenzaldehyde (EBA) and 2,4-difluoroaniline (DFA) were investigated using the zebrafish (Danio rerio) model. The two compounds, dissolved, were introduced in duplicate aquariums containing zebrafish in two different concentrations based on LC50 values. The aquarium water containing EBA or DFA was changed every 96 h throughout the 3 months of treatment. Behavior of the fish in each replicate was inspected twice daily. In course of treatment with both concentrations, fish exposed to DFA displayed behavior associated with visible anxiety, while EBA treated were lethargic and did not evade capture. Application of both concentrations of each component into the aquarium water resulted in dystrophic lesions in the liver, kidney and skin of the fish while preneoplastic lesions and tumors were not observed.

【 授权许可】

Unknown