Stereologic Analysis of Tissue Compartments of Gunshot-injured and Blunt-injured Spleen

Pathology & Oncology Research

Novica M. Milićević²  Cinthia B. Drachenberg¹  Živana Milićević²  Jasna B. Trbojević-Stanković³ 

[1] University of Maryland School of Medicine$$;Faculty of Medicine$$;Clinical Centre “Dr Dragiša Mišović�?$$

关键词: Splenic tissue compartments;   

DOI  :  10.1007/s12253-009-9189-2

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

The spleen is composed of several tissue compartments and the respective histoquantitative data are essential for complete understanding of immune or pathological processes in this organ. The aim of our study was to determine and compare the stereologic parameters of all tissue compartments of the gunshot-injured and blunt-injured human spleen. The model-based stereology with point-counting method was utilized to study the volume densities of red pulp, perifollicular zone, marginal zone, white pulp (follicles and periarteriolar lymphoid sheath), and connective tissue. The areal numerical density (the number of follicles per mm² of tissue section), the numerical density (the number of follicles per mm³ of tissue) of lymphoid follicles and the mean follicle diameter were also determined. Our study provides stereological parameters for all tissue compartments of the human spleen. No morphometric differences were registered between tissue compartments of the blunt-injured and gunshot-injured spleen. As the gunshot-injured spleen was taken as presumably unstimulated in immunological regard, our results suggest that both gunshot-injured and blunt-injured organs may be used as models of the normal human spleen.

【 授权许可】

Unknown