Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

Pathology & Oncology Research

Lei Cai¹  Yan Xiong¹  Shu-Guo Zheng¹  Jia-Hong Dong¹  Zhi-Bo Zhang² 

[1] Third Military Medical University$$;Third Military Medical University$$Fujian Medical University$$

关键词: Unpaired artery;   

DOI  :  10.1007/s12253-008-9144-7

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Caveolin-1 is the major structural protein in caveolae, implicated in oncogenesis and angiogenesis. The connections between caveolin-1 and progression and angiogenesis of hepatocellular carcinoma (HCC) is still not clear. Thus we investigated the relationship of caveolin-1 expression, vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and unpaired artery (UA) with the clinicopathologic features of patients with HCC. Formalin-fixed, paraffin-embedded tissue sections of HCC from 75 patients who had undergone an initial hepatectomy were stained immunohistochemically with specific antibodies against caveolin-1, VEGF, CD34 and α-SMA. The levels of caveolin-1, VEGF, MVD and UA were correlated with the clinicopathologic variables, and tissue sections were also analyzed by dual-label immunofluorescence. We found that increased expression of caveolin-1 was associated with metastasis and with a worse prognosis of HCC. Caveolin-1 expression correlates positively with VEGF, MVD and UA. These results suggest that caveolin-1 may play an important role in the progression of HCC and angiogenesis.

【 授权许可】

Unknown