Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

Zhi-Bo Zhang; Lei Cai; Shu-Guo Zheng; Yan Xiong; Jia-Hong Dong

doi:10.1007/s12253-008-9144-7

Pathology & Oncology Research

September 2009, 15:495

Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

Authors
Authors and affiliations

Zhi-Bo Zhang
Lei Cai
Shu-Guo Zheng
Yan Xiong
Jia-Hong DongEmail author

Original Paper

First Online:: 12 May 2009

Received:: 08 November 2008
Accepted:: 18 December 2008

DOI: 10.1007/s12253-008-9144-7

Cite this article as:: Zhang, ZB., Cai, L., Zheng, SG. et al. Pathol. Oncol. Res. (2009) 15: 495. doi:10.1007/s12253-008-9144-7

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Abstract

Caveolin-1 is the major structural protein in caveolae, implicated in oncogenesis and angiogenesis. The connections between caveolin-1 and progression and angiogenesis of hepatocellular carcinoma (HCC) is still not clear. Thus we investigated the relationship of caveolin-1 expression, vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and unpaired artery (UA) with the clinicopathologic features of patients with HCC. Formalin-fixed, paraffin-embedded tissue sections of HCC from 75 patients who had undergone an initial hepatectomy were stained immunohistochemically with specific antibodies against caveolin-1, VEGF, CD34 and α-SMA. The levels of caveolin-1, VEGF, MVD and UA were correlated with the clinicopathologic variables, and tissue sections were also analyzed by dual-label immunofluorescence. We found that increased expression of caveolin-1 was associated with metastasis and with a worse prognosis of HCC. Caveolin-1 expression correlates positively with VEGF, MVD and UA. These results suggest that caveolin-1 may play an important role in the progression of HCC and angiogenesis.

Keywords

Caveolin-1 Vascular endothelial growth factor Angiogenesis Metastasis Prognosis Hepatocellular carcinoma Microvessel density Unpaired artery

Abbreviations

HCC: hepatocellular carcinoma
MVD: microvessel density
UA: unpaired artery
VEGF: vascular endothelial growth factor
α-SMA: alpha smooth muscle actin
SECs: sinusoidal endothelial cells
MDN: macroregenerative and dysplastic nodules

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Authors and Affiliations

Zhi-Bo Zhang
- 1
- 2
Lei Cai
- 1
Shu-Guo Zheng
- 1
Yan Xiong
- 1
Jia-Hong Dong
- 1
Email author

1.Institute of Hepatobiliary Surgery & Southwest HospitalThird Military Medical UniversityChongqingPeople’s Republic of China
2.Department of Hepatopancreatobiliary Surgery, The First Affiliated HospitalFujian Medical UniversityFuzhouPeople’s Republic of China

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Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

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