Microvessel count, proliferating cell nuclear antigen and Ki-67 indices in gastric adenocarcinoma

Pathology & Oncology Research

Tekinalp Gelen¹  Tuncer Karpuzoğlu¹  Nazif Hikmet Aksoy¹  Gülsüm Özlem Elpek¹  Nuran Keles¹ 

[1] Akdeniz University, Medical School$$

关键词: gastric carcinoma;   

DOI  :  10.1007/BF03032660

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

The aim of the present study was to immunohistochemically investigate the prognostic value of neovascularization (expressed as microvessel count-MVC) and tumor cell proliferation (expressed as PCNA labeling index - PLI and Ki-67 labeling index- KLI) in gastric adenocarcinoma. Correlations with clinicopathologic features were also evaluated. Tumor specimens from 74 patients diagnosed as gastric adenocarcinoma were included in this study. For-malin fixed, paraffin embedded tissue sections stained immunohistochemically with F-VIII, PC10 and MIB-1 monoclonal antibodies. By ocular grid subdivided into 100 areas, number of microvessels and PC10, MIB-1 positive and negative cells were counted at x400 magnification. Chi-square test, Kaplan-Meier method and cox regression analysis were used for statistical analysis. The results showed that, MVC and PLI had a significant correlation with invasion and lymph node metastasis. The prognosis was significantly worse in patients with high MVC (>14) and with high PLI (>49%). However any relationship was not observed between KLI (38%) and clinicopathologic parameters, so KLI failed to predict the prognosis. Cox model showed that, MVC and PLI were independent prognostic variables. Ki-67 labeling index in gastric carcinomas has no prognostic relevance. However, the evaluation of microvessel count and proliferating cell nuclear antigen index in gastric carcinomas could be reliable indicators of prognosis.

【 授权许可】

Unknown