Role of complement and antibodies in the control and facilitation of HIV disease

Pathology & Oncology Research

Dénes BÁnhegyi³  George FÜst²  Zoltán ProhÁszka²  Ferenc D TÓth¹ 

[1] University Medical School$$;Semmelweis Medical University of Medicine$$National Academy of Sciences$$;St. László Hospital$$

关键词: C1q;   

DOI  :  10.1007/BF02904290

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

In humans the HIV infection results in a chronic disease with a permanent fight between factors controlling HIV and the escape of the virus. Fromthese control mechanisms the present review summarizes the role betwen complement and autoantibodies; the competition of complement and anti-HIV antibodies for binding sites, the role of mannan-binding lectin in the susceptibility to and in the survival after HIV infection, the contribution of complement-dependent enhancing type antibodies to the clinical progression of HIV disease as well as the changing pattern of some autoantibodies (mimicking MHC class II molecules, anti-heat shock protein 60 antibodies and anti-C1q antibodies) which were found to correlate to immunological and clinical parameters.

【 授权许可】

Unknown