Role of complement and antibodies in the control and facilitation of HIV disease Zoltán ProhÁszka Email author Ferenc D TÓth Dénes BÁnhegyi George FÜst Special report Received: 31 October 1997 Accepted: 26 November 1997 DOI :
10.1007/BF02904290
Cite this article as: ProhÁszka, Z., TÓth, F.D., BÁnhegyi, D. et al. Pathol. Oncol. Res. (1997) 3: 296. doi:10.1007/BF02904290 Abstract In humans the HIV infection results in a chronic disease with a permanent fight between factors controlling HIV and the escape of the virus. Fromthese control mechanisms the present review summarizes the role betwen complement and autoantibodies; the competition of complement and anti-HIV antibodies for binding sites, the role of mannan-binding lectin in the susceptibility to and in the survival after HIV infection, the contribution of complement-dependent enhancing type antibodies to the clinical progression of HIV disease as well as the changing pattern of some autoantibodies (mimicking MHC class II molecules, anti-heat shock protein 60 antibodies and anti-C1q antibodies) which were found to correlate to immunological and clinical parameters.
Key words HIV complement gp41 gp120 mannan-binding lectin enhancing antibodies autoantibodies heat-shock protein 60 C1q
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Authors and Affiliations Zoltán ProhÁszka Email author Ferenc D TÓth Dénes BÁnhegyi George FÜst 1. 3rd Department of Medicine, Research Laboratory Semmelweis Medical University of Medicine Budapest Hungary 2. Research Group for Membrane Biology and Immunopathology National Academy of Sciences Budapest 3. Institute of Microbiology University Medical School Debrecen 4. Department of Immunology St. László Hospital Budapest Hungary