Thrombospondins in the heart: potential functions in cardiac remodeling

Journal of Cell Communication and Signaling

E. Helene Sage²  Mark W. M. Schellings¹  Stephane Heymans¹  Geert C. van Almen¹ 

[1] Maastricht University$$;Hope Heart Program, Benaroya Research Institute at Virginia Mason$$

关键词: Myocardial infarction;   

DOI  :  10.1007/s12079-009-0070-6

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. Thrombospondins (TSPs) belong to the group of matricellular proteins, which are non-structural extracellular matrix proteins that modulate cell–matrix interactions and cell function in injured tissues or tumors. They interact with different matrix and membrane-bound proteins due to their diverse functional domains. That the expression of TSPs strongly increases during cardiac stress or injury indicates an important role for them during cardiac remodeling. Recently, the protective properties of TSP expression against heart failure have been acknowledged. The current review will focus on the biological role of TSPs in the ischemic and hypertensive heart, and will describe the functional consequences of TSP polymorphisms in cardiac disease.

【 授权许可】

Unknown