Dynamic instability — A common denominator in prokaryotic and eukaryotic DNA segregation and cell division

Cellular & Molecular Biology Letters

John A. Fuesler¹  Hsin-Jung Sophia Li¹ 

[1] Department of Molecular Biology, Princeton University, Princeton, USA$$

关键词: Dynamic instability;    Microtubules;    ParM filaments;    R1 plasmid;    Mitosis;    Mitotic spindle;    Brownian ratchet;    Cytoskeleton evolution;    Catastrophe/recovery;   

DOI  :  10.2478/s11658-012-0026-3

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Dynamic instability is an essential phenomenon in eukaryotic nuclear division and prokaryotic plasmid R1 segregation. Although the molecular machines used in both systems differ greatly in composition, strong similarities and requisite nuances in dynamics and segregation mechanisms are observed. This brief examination of the current literature provides a functional comparison between prokaryotic and eukaryotic dynamically unstable filaments, specifically ParM and microtubules. Additionally, this mini-review should support the notion that any dynamically unstable filament could serve as the molecular machine driving DNA segregation, but these machines possess auxiliary features to adapt to temporal and spatial disparities in either system.

【 授权许可】

Unknown