Cellular & Molecular Biology Letters | |
SHP-2 and PTP-pest induction during Rb-E2F associated apoptosis | |
Jonathan H. Lieman3  Dae Joon Kim2  Liza D. Morales1  Karina Pena3  | |
[1] Department of Biology, The University of Texas-Pan American, Edinburg, USA$$Edinburg Regional Academic Health Center, Medical Research Division, University of Texas Health Science Center at San Antonio, Edinburg, USA$$;Department of Pharmacology, University of Texas Health Science Center at San Antonio, Edinburg, USA$$Edinburg Regional Academic Health Center, Medical Research Division, University of Texas Health Science Center at San Antonio, Edinburg, USA$$;Department of Biology, The University of Texas-Pan American, Edinburg, USA$$ | |
关键词: Apoptosis; Focal adhesion kinase; Rb; E2F-1; Phosphatase; PTP-1B; SHP-2; PTP-PEST; PTPN1; PTPN11; PTPN12; Tumor suppressor; | |
DOI : 10.2478/s11658-012-0020-9 | |
学科分类:分子生物学,细胞生物学和基因 | |
来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology | |
【 摘 要 】
Apoptosis is intimately connected to cell cycle regulation via the Retinoblastoma (Rb)-E2F pathway and thereby serves an essential role in tumor suppression by eliminating aberrant hyperproliferative cells. Upon loss of Rb activity, an apoptotic response can be elicited through both p53-dependent and p53-independent mechanisms. While much of this apoptotic response has been attributed to the p19ARF/p53 pathway, increasing evidence has supported the role of protein tyrosine phosphatases (PTPs) in contributing to the initiation of the Rb-E2F-associated apoptotic response. One protein tyrosine phosphatase, PTP-1B, which is induced by the Rb-E2F pathway, has been shown to contribute to a p53-independent apoptotic pathway by inactivating focal adhesion kinase. This report identifies two additional PTPs, SHP-2 and PTP-PEST, that are also directly activated by the Rb-E2F pathway and which can contribute to signal transduction during p53-independent apoptosis.
【 授权许可】
Unknown
【 预 览 】
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RO201912040504130ZK.pdf | 361KB | download |