Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

Cellular & Molecular Biology Letters

Hesheng Hou¹  Li Han²  Qiu Yan²  Xiao-Qi Wang⁴  Xuesong Yang²  Shaoming Tong³  Hongyan Li³  Jiwei Liu⁵ 

[1] College of Life Science, Liaoning Normal University, Dalian, Liaoning, People’s Republic of China$$;Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning, People’s Republic of China$$;Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning, People’s Republic of China$$College of Life Science, Liaoning Normal University, Dalian, Liaoning, People’s Republic of China$$;Departments of Dermatology and Pediatrics, Northwestern University’s Feinberg School of Medicine, Chicago, USA$$;Department of Oncology, 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China$$

关键词: Fucosyltransferase;    Methylation;    A431 cells;    SCC12 cells;   

DOI  :  10.2478/s11658-012-0003-x

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.

【 授权许可】

Unknown