Circulating nucleic acids as a new diagnostic tool

Cellular & Molecular Biology Letters

Marketa Urbanova⁴  Hynek Strnad²  Jan Plzak¹  Jan Betka³ 

[1] 1st Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty Hospital Motol, Institute of Postgraduate Medicine, Charles University, Prague 5, Czech Republic$$2nd Faculty of Medicine, Centre of Cell Therapy and Tissue Repair, Charles University, Prague 5, Czech Republic$$1st Faculty of Medicine, Institute of Anatomy, Charles University, Prague 2, Czech Republic$$;Institute of Molecular Genetics, Department of Genomics and Bioinformatics, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic$$;1st Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty Hospital Motol, Institute of Postgraduate Medicine, Charles University, Prague 5, Czech Republic$$;1st Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty Hospital Motol, Institute of Postgraduate Medicine, Charles University, Prague 5, Czech Republic$$Institute of Molecular Genetics, Department of Genomics and Bioinformatics, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic$$

关键词: Circulating nucleic acids;    RNA;    DNA;    Diagnostics;    Cancer;   

DOI  :  10.2478/s11658-010-0004-6

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

The discovery of circulating nucleic acids in the 1940s opened up new possibilities for the non-invasive detection, monitoring and screening of various human disorders. Several tumour markers that enable early cancer detection or tumour behaviour prediction have been detected in the plasma of cancer patients. Maternal plasma analysis can be used to detect certain fetal abnormalities, with the quantification of cell-free nucleic acids used to screen for several pregnancy-associated disorders. Some other applications are in transplant monitoring and graft rejection assessment, and in certain medical emergencies such as trauma and burn severity stratification. Many studies have yielded promising results in this field, but the techniques have yet to be applied in routine clinical practice. Large-scale studies using similar technologies and a broad spectrum of patients are still needed to verify the results of the various studies.

【 授权许可】

Unknown