Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells

Cellular & Molecular Biology Letters

Wei Tian²  Xiu-Mei Sui¹  Dao-Qiang Zhang¹  Ya-Jun Liu² 

[1] Wendeng Central Hospital, Weifang Medical College, Weihai, Shandong Province, P. R. China$$;Beijing Jishuitan Hospital, Peking University, Beijing, P. R. China$$

关键词: Osteopontin;    Overexpression;    Proliferation;    Metastasis;   

DOI  :  10.2478/s11658-009-0027-z

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G1/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.

【 授权许可】

Unknown