The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

Cellular & Molecular Biology Letters

Irma Podolak²  Agnieszka Galanty²  Marta Michalik¹  Łukasz Sędek¹ 

[1] Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland$$;Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University, Kraków, Poland$$

关键词: Triterpene saponoside;    Cytotoxicity;    Melanoma;    Fibroblasts;   

DOI  :  10.2478/s11658-008-0013-x

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility.

【 授权许可】

Unknown