Risk of Cerebral Infarction in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study (MID study)

Kidney and Blood Pressure Research

Fujimoto S.¹  Komatsu H.³  Hisanaga S.⁴  Kitamura K.²  Uezono S.¹  Ishihara T.¹  Nakagawa H.¹  Sato Y.¹  Yamada K.⁵  Toida T.² 

[1] Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki; $$;First Department of Internal Medicine, University of Miyazaki Hospital; $$;Department of Internal Medicine, Koga General Hospital; $$;Department of Internal Medicine, Miyazaki Social Insurance Hospitali; $$

关键词: End stage renal disease;    Hemodialysis;    Cerebral infarction;    Risk factor;   

DOI  :  10.1159/000443448

来源: S Karger AG

【 摘 要 】

Background/Aims: Predictors including the preventive effects of antiplatelet and anticoagulant drugs on cerebral infarction (CI) events have not yet been clarified in dialysis patients. The aim of the present study was to examine the risk of CI and preventive effects of these drugs in Japanese hemodialysis patients. Methods: Patients receiving maintenance hemodialysis (n=1,551, median age (interquartile range), 69.0 (59.0-78.0) years; 41.5% female) were enrolled in the Miyazaki Dialysis Cohort Study and prospectively followed-up for 3 years. Kaplan-Meier and Cox's regression analyses were used to clarify the risk of CI. Results: Eighty-four patients developed CI at an incidence of 21.5/1000 patients per year. The presence of a previous history of CI, atrial fibrillation (AF), and diabetes mellitus in addition to age were also identified as predictive factors for new CI, whereas no relationship was observed between antiplatelet and/or anticoagulant usage and CI. Furthermore, no significant difference was noted in the frequency of CI events between patients with AF who received warfarin and those who did not. Conclusions: The incidence of CI was higher in dialysis patients with a previous history of CI and AF; however, the preventive effects of antiplatelet/anticoagulant drugs on the development of CI were not evident.

【 授权许可】

Unknown