The Impact of Exercising During Haemodialysis on Blood Pressure, Markers of Cardiac Injury and Systemic Inflammation - Preliminary Results of a Pilot Study

Kidney and Blood Pressure Research

Bishop N.C.¹  Burton J.O.²  Young H.M.L.³  Dungey M.³  Smith A.C.² 

[1] Leicester Kidney Exercise Team, John Walls Renal Unit, University Hospitals of Leicester, $$Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire, United Kingdom$$;Leicester Kidney Exercise Team, John Walls Renal Unit, University Hospitals of Leicester, $$

关键词: Blood pressure;    Cardiovascular disease;    Exercise;    Haemodialysis;    Inflammation;   

DOI  :  10.1159/000368535

来源: S Karger AG

【 摘 要 】

Background/Aims: Patients requiring haemodialysis have cardiovascular and immune dysfunction. Little is known about the acute effects of exercise during haemodialysis. Exercise has numerous health benefits but in other populations has a profound impact upon blood pressure, inflammation and immune function; therefore having the potential to exacerbate cardiovascular and immune dysfunction in this vulnerable population. Methods: Fifteen patients took part in a randomised-crossover study investigating the effect of a 30-min bout of exercise during haemodialysis compared to resting haemodialysis. We assessed blood pressure, plasma markers of cardiac injury and systemic inflammation and neutrophil degranulation. Results: Exercise increased blood pressure immediately post-exercise; however, 1 hour after exercise blood pressure was lower than resting levels (106±22 vs. 117±25 mm Hg). No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms. Exercise did not alter circulating concentrations of IL-6, TNF-α or IL-1ra nor clearly suppress neutrophil function. Conclusions: This study demonstrates fluctuations in blood pressure during haemodialysis in response to exercise. However, since the fall in blood pressure occurred without evidence of cardiac injury, we regard it as a normal response to exercise superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well tolerated.

【 授权许可】

Unknown