Collective dynamics of multicellular systems

Pramana

R Maithreye1¹  Somdatta Sinha1¹  C Suguna1¹ 

[1] Centre for Cellular and Molecular Biology (CSIR), Uppal Road, Hyderabad 500 007, India$$

关键词: Nonlinear regulation;    bistable;    oscillations;    biochemical pathway;    synchronization;    multicell system.;   

DOI  :  

学科分类：物理（综合）

来源: Indian Academy of Sciences

【 摘 要 】

We have studied the collective behaviour of a one-dimensional ring of cells for conditions when the individual uncoupled cells show stable, bistable and oscillatory dynamics. We show that the global dynamics of this model multicellular system depends on the system size, coupling strength and the intrinsic dynamics of the cells. The intrinsic variability in dynamics of the constituent cells are suppressed to stable dynamics, or modified to intermittency under different conditions. This simple model study reveals that cell–cell communication, system size and intrinsic cellular dynamics can lead to evolution of collective dynamics in structured multicellular biological systems that is significantly different from its constituent single-cell behaviour.

【 授权许可】

Unknown