Death, dynamics and disorder: Terminating reentry in excitable media by dynamically-induced inhomogeneities

Pramana

Sitabhra Sinha1¹  Johannes Breur1¹ 

[1] The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600 113, India$$

关键词: Reentry;    tachycardia;    pacing;    disorder.;   

DOI  :  

学科分类：物理（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Formation of feedback loops of excitation waves (reentrant circuit) around non-conducting ventricular scar tissue is a common cause of cardiac arrhythmias, such as ventricular tachycardia, often leading to death. This is typically treated by rapid stimulation from an implantable device (ICD). However, the mechanisms of reentry termination success and, more importantly, failure, are poorly understood. To study such mechanisms, we simulated pacing termination of reentry in a model of cardiac tissue having significant restitution and dispersion properties. Our results show that rapid pacing dynamically generates conduction inhomogeneities in the reentrant circuit, leading to successful pacing termination of tachycardia. The study suggests that more effective pacing algorithms can be designed by taking into account the role of such dynamical inhomogeneities.

【 授权许可】

Unknown