Molecular mechanism of Endosulfan action in mammals

Journal of biosciences

SATHEES C RAGHAVAN1¹  ROBIN SEBASTIAN¹ 

[1] Department of Biochemistry, Indian Institute of Science, Bengaluru 560 012, India$$

关键词: DNA damage;    double-strand break;    genomic instability;    infertility;    MMEJ;    NHEJ;    pesticides;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Endosulfan is a broad-spectrum organochlorine pesticide, speculated to be detrimental to human health in areas ofactive exposure. However, the molecular insights to its mechanism of action remain poorly understood. In two recentstudies, our group investigated the physiological and molecular aspects of endosulfan action using in vitro, ex vivo andin vivo analyses. The results showed that apart from reducing fertility levels in male animals, Endosulfan inducedDNA damage that triggers compromised DNA damage response leading to undesirable processing of broken DNAends. In this review, pesticide use especially of Endosulfan in the Indian scenario is summarized and the importance ofour findings, especially the rationalized use of pesticides in the future, is emphasized.

【 授权许可】

Unknown