Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats

Journal of biosciences

SANJAY K BANERJEE²  K PRAVEEN KUMAR³  SUMANA CHAKRAVARTY2²  PANKAJ K BAGUL²  SWATI MAITRA³  GAGANDEEP KAUR²  B RAGHUNATH REDDY³  PRIYA JHELUM³  ARVIND KUMAR¹ 

[1]Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Habsiguda, Hyderabad 500 007, India$$

[2]Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India$$

[3]Chemical Biology, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India$$

关键词: Epigenetic;    fructose;    metformin;    mood disorders;    sirtuins;    type 2 diabetes;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Hyperglycaemia in diabetes is either caused by reduced availability of insulin (type 1 diabetes, T1D) or insulinresistance to the cells (type 2 diabetes, T2D). In recent years, the prevalence of T2D has increased to an alarmingproportion, encompassing 95% of the total diabetic burden, probably due to economy-driven changes in lifestyle.Recent epidemiological studies show comorbid depression, anxiety and related mental illness. To explore themolecular mechanisms underlying this comorbid conditions, we used Sprague–Dawley rats on high-fructose dietfor 8 weeks to induce prediabetic condition. Rats with this metabolic syndrome also showed hyper-anxiety when theywere subjected to anxiety-related behavioural assays. Rats were administered with resveratrol, an activator of sirtuins,and metformin, a standard antidiabetic drug, simultaneously with fructose. We observed that resveratrol was moreeffective in protecting from both the metabolic (prediabetic) and affective (anxiety) disorders than metformin.Molecular studies showed that recovery was associated with the upregulation of few nuclear sirtuins that actepigenetically – Sirt 1 and 7, which were significantly attenuated in the striatum of prediabetic rats. In conclusion,our study showed that hyper-anxiety associated with prediabetic condition is ameliorated by resveratrol throughmodulation of sirtuins, which is more or less similar to metformin.

【 授权许可】

Unknown