Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts

Journal of biosciences

Lu Liu¹  Wei Feng¹  Manxiang Li1¹  Guizuo Wang¹  Jiamei Lu¹  Xinming Xie¹  Dong Han¹  Shaojun Li¹  Yanting Zhu¹  Yilin Pan¹ 

[1] Respiratory Diseases Research Center, and Department of Respiratory Medicine, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi'an, Shaanxi, 710004, P.R. China$$

关键词: Airway fibroblasts;    collagen I;    interleukin-13;    PDGF;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Interleukin-13 (IL-13) is associated with the production of collagen in airway remodelling of asthma. Yet, the molecular mechanisms underlying IL-13 induction of collagen remain unclear; the aim of this study is to address this issue. IL-13 dose- and time-dependently-induced collagen I production in primary cultured airway fibroblasts; this was accompanied with the STAT6 phosphorylation, and pre-treatment of cells with JAK inhibitor suppressed IL-13-induced collagen I production. Further study indicated that IL-13 stimulated JAK/STAT6-dependent PDGF production and subsequent ERK1/2 MAPK activation in airway fibroblasts, and the presence of either PDGF receptor blocker or MEK inhibitor partially suppressed IL-13-induced collagen I production. Taken together, our study suggests that activation of JAK/STAT6 signal pathway and subsequent PDGF generation and resultant ERK1/2 MAPK activation mediated IL-13-induced collagen I production in airway fibroblasts.

【 授权许可】

Unknown