Competing views on cancer

Journal of biosciences

Ana M Soto1 2²  Annapoorni Rangarajan3¹  Carlos Sonnenschein1²  Prakash Kulkarni4³ 

[1] Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560 012, India$$;Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA$$;Department of Urology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA$$

关键词: Cancer;    histogenesis;    intrinsically disordered proteins;    morphogenesis;    protein interaction network;    stroma-epithelium interaction;    tissue organization field theory;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Despite intense research efforts that have provided enormous insight, cancer continues to be a poorly understood disease. There has been much debate over whether the cancerous state can be said to originate in a single cell or whether it is a reflection of aberrant behaviour on the part of a ‘society of cells’. This article presents, in the form of a debate conducted among the authors, three views of how the problem might be addressed. We do not claim that the views exhaust all possibilities. These views are the tissue organization field theory (TOFT) that is based on a breakdown of tissue organization involving many cells from different embryological layers,

【 授权许可】

Unknown