Stem cell function and maintenance - ends that matter: Role of telomeres and telomerase

Journal of biosciences

Hamid Saeed1²  Mehwish Iqtedar¹ 

[1] Department of Bio-technology & Microbiology, Lahore College for Women University, Lahore, Pakistan$$;Department of Endocrinology, School of Medicine, Stanford University, Stanford, CA, USA$$

关键词: Aging;    stem cells;    telomerase;    telomeres;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive agerelated degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.

【 授权许可】

Unknown