Genome-based versus gene-based theory of cancer: Possible implications for clinical practice

Journal of biosciences

NataÅ¡a Todorović-Raković1¹ 

[1] Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia$$

关键词: Cancer theories;    genome variations;    HER2;    oncogene;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The current state in oncology research indicates that the attempts to explain such complex process as cancerogenesis by a single or several genetic mutations were not successful enough. On the other hand, chromosomal/genomic instability – almost universal features of malignant tumours which influence a global pattern of gene expression and, subsequently, many oncogenic pathways – were often disregarded and considered nonessential to clinical application. However, a new arising field of system biology including ‘new forms’ of genome diversity such as copy number variations (CNV) and high-throughput oncogene mutation profiling now reveal all the complexity of cancer and provide the final explanation of the oncogenic pathways, based on stochastic (onco)genomic variation rather than on (onco)genic concepts.

【 授权许可】

Unknown