A novel pathogenic classification of cancers

Cancer Cell International

Ana M Soto¹  Barbara Davis¹  Carlos Sonnenschein¹ 

[1] Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston 02111, MA, USA

关键词: Cancer theories;    Tissue organization field;    Mutation;    Neoplasia;    Metastasis;    Pathobiology;    Carcinogenesis;   

Others  :  1121626
DOI  :  10.1186/s12935-014-0113-9

 received in 2014-09-15, accepted in 2014-10-23,  发布年份 2014

【 摘 要 】

According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer. This new scheme first defines cancers as either 1.inborn errors of development or 2.sporadic ones, and then sub-defines the former into 1A. inborn inherited errors of development, being those due to mutations contributed by one or both parents’ gametes to the developing conceptus, and 1B. inborn induced errors of development when the malformations and/or cancers are due to environmental carcinogenic exposure during pregnancy. It is anticipated that the origin of an increasing number of so-called sporadic cancers will turn out to be linked to the inborn induced errors of development group.

【 授权许可】

   
2014 Sonnenschein et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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