Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro

Journal of biosciences

Maithili P Dalvi¹  Malati R Umrani¹  Mugdha V Joglekar¹  Anandwardhan A Hardikar1¹ 

[1] Stem Cells and Diabetes Section, Lab 12, National Center for Cell Science, Ganeshkhind Road, Pune 411 007, India$$

关键词: Differentiation;    EMT;    pancreas;    plasticity;    progenitor;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.

【 授权许可】

Unknown