Redifferentiation of human hepatoma cells (SMMC-7721) induced by two new highly oxygenated bisabolane-type sesquiterpenes

Journal of biosciences

Jinbo Yang1 2¹  Ruidong Miao¹  Q I Zhang¹  Qin Wang1¹  Juan Wei¹  Venkateswara Sajja² 

[1] School of Life Sciences, Lanzhou University, Lanzhou 730000, P R China$$;Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA$$

关键词: Oxygenated bisabolane-type sesquiterpenes (HOBS);    proliferation;    redifferentiation;    tumour;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Bisabolane-type sesquiterpenes are a class of biologically active compounds that has antitumour, antifungal, antibacterial, antioxidant and antivenom properties. We investigated the effect of two new highly oxygenated bisabolane-type sesquiterpenes (HOBS) isolated from Cremanthodium discoideum (C. discoideum) on tumour cells. Our results showed that HOBS induced morphological differentiation and reduced microvilli formation on the cell surface in SMMC-7721 cells. Flow cytometry analysis demonstrated that HOBS could induce cell-cycle arrest in the G1 phase. Moreover, HOBS was able to increase tyrosine-𝛼-ketoglutarate transaminase activity, decrease 𝛼-foetoprotein level and 𝛾-glutamyl transferase activity. In addition, we found that HOBS inhibited the anchorage-independent growth of SMMC-7721 cells in a dose-dependent manner. Taken together, all the above observations indicate that HOBS might be able to normalize malignant SMMC-7721 cells by inhibiting cell proliferation and inducing redifferentiation.

【 授权许可】

Unknown