Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients: a pilot study

Journal of Nutritional Science

Robert W. Owen⁵  Cornelia M. Ulrich⁵  Roswitha Haubner⁵  Thomas A. Sellers⁴  Jana Kotzmann⁵  Kathy Vickers³  Erin M. Siegel⁴  David Shibata⁴  William Grady³  Gerd Würtele⁵  Michael Hoffmeister⁶  Hermann Brenner⁶  Heiko Becher²  Jenny Chang-Claude⁶  Karen Makar³  Xiaoling Song³  Clare Abbenhardt⁵  Adetunji T. Toriola¹  Shannon K. Rush³ 

[1]Washington University School of Medicine and Siteman Cancer Center

[2]University of Heidelberg

[3]Fred Hutchinson Cancer Research Center

[4]H. LeeMoffitt Cancer Center

[5]National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)

[6]German Cancer Research Center (DKFZ)

关键词: Colorectal cancer;    Survival;    Vitamin D;    Vitamin B12;    Folate;   

DOI  :  10.1017/jns.2012.28

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Using a sequential in vitro/in vivo approach, we tested the ability of botanical extracts to influence biomarkers associated with bone resorption and bone formation. Pomegranate fruit and grape seed extracts were found to exhibit anti-resorptive activity by inhibiting receptor activator of nuclear factor-κB ligand (RANKL) expression in MG-63 cells and to reduce IL-1β-stimulated calvarial 45Ca loss. A combination of pomegranate fruit and grape seed extracts were shown to be effective at inhibiting bone loss in ovariectomised rats as demonstrated by standard histomorphometry, biomechanical and bone mineral density measurements. Quercetin and licorice extract exhibited bone formation activity as measured by bone morphogenetic protein-2 (BMP-2) promoter activation, increased expression of BMP-2 mRNA and protein levels, and promotion of bone growth in cultured mouse calvariae. A combination of quercetin and licorice extract demonstrated a potential for increasing bone mineral density in an intact female rat model as compared with controls. The results from this sequential in vitro/in vivo research model yielded botanical extract formulas that demonstrate significant potential benefits for bone health.

【 授权许可】

Unknown