Substitution of TAG oil with diacylglycerol oil in food items improves the predicted 10 years cardiovascular risk score in healthy, overweight subjects

Journal of Nutritional Science

Annhild Mosdøl⁴  Amandine Lamglait³  Kjetil Retterstøl¹  Bente Halvorsen²  Ingunn Narverud⁴  Kirsti Forstrøm Christiansen³  Kirsten B. Holven¹  Nima Wesseltoft-Rao⁴  Linda Granlund³  Vibeke H. Telle-Hansen⁴  Stine M. Ulven⁴ 

[1] Institute for Basic Medical Sciences, University of Oslo;Research Institute for Internal Medicine, Faculty of Medicine, University of Oslo, Rikshospitalet, Oslo University Hospital;Vibeke H. Telle-Hansen;Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences

关键词: Diacylglycerol;    TAG;    Overweight human subjects;    Liver markers;   

DOI  :  10.1017/jns.2012.18

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Using a sequential in vitro/in vivo approach, we tested the ability of botanical extracts to influence biomarkers associated with bone resorption and bone formation. Pomegranate fruit and grape seed extracts were found to exhibit anti-resorptive activity by inhibiting receptor activator of nuclear factor-κB ligand (RANKL) expression in MG-63 cells and to reduce IL-1β-stimulated calvarial 45Ca loss. A combination of pomegranate fruit and grape seed extracts were shown to be effective at inhibiting bone loss in ovariectomised rats as demonstrated by standard histomorphometry, biomechanical and bone mineral density measurements. Quercetin and licorice extract exhibited bone formation activity as measured by bone morphogenetic protein-2 (BMP-2) promoter activation, increased expression of BMP-2 mRNA and protein levels, and promotion of bone growth in cultured mouse calvariae. A combination of quercetin and licorice extract demonstrated a potential for increasing bone mineral density in an intact female rat model as compared with controls. The results from this sequential in vitro/in vivo research model yielded botanical extract formulas that demonstrate significant potential benefits for bone health.

【 授权许可】

Unknown