Hepatic microsomal triglyceride transfer protein messenger RNA concentrations are increased by dietary cholesterol in hamsters

FEBS Letters

Bennett, Andrew J.²  Bruce, Jennifer S.¹  Billett, Michael A.²  White, David A.²  Salter, Andrew M.¹ 

[1] Department of Applied Biochemistry and Food Science, University of Nottingham Sutton Bonington Campus, Loughborough LE12 5RD, UK;Department of Biochemistry, University of Nottingham Medical School, Nottingham NG7 2UH, UK

关键词: Hepatic microsomal triglyceride transfer protein;    mRNA;    Dietary cholesterol;    Very low density lipoprotein secretion;    Golden Syrian hamster liver;    VLDL;    very low density lipoprotein;    apoB;    apolipoprotein B;    MTP;    microsomal triglyceride transfer protein;    chol;    cholesterol;    TAG;    triacylglycerol;    PAP-1;    phosphatidate phosphohydrolase-1;    LDL;    low density lipoprotein;    HDL;    high density lipoprotein;   

DOI  :  10.1016/0014-5793(96)00962-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In hamsters fed high fat diets enriched in trimyristin, tripalmitin or tristearin, increased dietary cholesterol content was associated with increased plasma concentrations of very low density lipoprotein (VLDL) cholesterol and triacylglycerol (p < 0.0001 and p = 0.0017, respectively). Hepatic microsomal triglyceride transfer protein (MTP) mRNA concentration also increased (p < 0.0001), independent of the nature of dietary fat, and was significantly correlated with the plasma VLDL lipid concentrations (p = 0.0002 and p = 0.0106 for cholesterol and triacylglycerol, respectively) and hepatic cholesterol concentrations. Increased expression of the MTP gene may be part of a coordinated response to hepatic cholesterol accumulation leading to increased VLDL lipid secretion.

【 授权许可】

Unknown