Exercise improves global well-being in adults with fibromyalgia: confirmation of previous meta-analytic results using a recently developed and novel varying coefficient model

Clinical and Experimental Rheumatology

Kristi S. Kelley¹  George A. Kelley¹ 

关键词: Fibromyalgia;    exercise;    meta-analysis;    rheumatology;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: To determine the effects of exercise (aerobic, strength training or both) on global well-being in adults with fibromyalgia (FM). METHODS: The meta-analytic approach and recently developed varying coefficient model were used to pool the results of previous randomised controlled trials of exercise (aerobic, strength training or both) on global well-being in adults with FM. The standardised effect size (ES) for global well-being from each study was pooled using a recently developed and novel varying coefficient (VC) model and partitioned according to per-protocol and intention-to-treat analyses. Results were also compared to the traditionally used random effects (RE) model. Non-overlapping 95% confidence intervals were considered statistically significant with negative ESs indicative of improvements in global well-being. RESULTS: Five ESs representing 377 participants were included in the per-protocol analysis and 5 ESs representing 252 participants were included in the intention-to-treat analysis. Using the VC model, statistically significant improvements in global-well being were found for both per-protocol (–X, -0.39, 95% CI, -0.62, -0.15) and intention-to-treat analysis (–X, -0.40, 95% CI, -0.68, -0.13). Results were similar to those from the RE model. CONCLUSIONS: Using the recently developed and more valid varying coefficient model, these findings confirm that exercise improves global-well being in adults with FM.

【 授权许可】

Unknown