Baseline characteristics of the population enrolled in the Italian Observational Study on Severe Osteoporosis (ISSO)

Clinical and Experimental Rheumatology

Domenico Valle¹  V Camozzi¹  Vincenzo Toscano¹  Giangiacomo Osella¹  Domenico Maugeri¹  Giovanni Iolascon¹  Anna Brancati¹  Nazzarena Malavolta¹  Libuse Tauchmanov๠ Silvia Migliaccio¹  Gaetano Topa¹  Maurizio Carminiti¹  C Corradini¹  Silvano Adami¹  Giuseppina Resmini¹  Sandra Silvestri¹  Alfredo Nardi¹  C Cagnoni¹  Marco Massarotti¹  FM Ulivieri¹ 

关键词: Osteoporosis;    observational study;    risk factors;    fractures;    back pain;    treatment;    quality of life;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: Baseline characteristics of the population enrolled in the ISSO study, designed to evaluate the incidence of vertebral and non-vertebral fractures in Italian patients with severe osteoporosis treated according to clinical practice over 24 months observation. METHODS: Prospective observational study in 783 post-menopausal women and men entering 18-month treatment with teriparatide in a community setting at 57 centres in Italy. Characterisation included demographics, fracture risk factors, bone mineral density, fracture status, Health-Related Quality of Life (HRQoL) measured by the European Quality of Life Questionnaire, EQ-5D, and back pain assessed by VAS. RESULTS: Most patients were elderly women (90.5%), mean age±SD was 72.9±8.8 years. Nearly all (91.3%) had experienced ≥1 vertebral fracture (mean±SD, 3.6±2.2 per patient), 37.5% had ≥1 non-vertebral fracture (mean±SD, 1.4±0.7 per patient). Nearly all patients were suffering from back pain (94.9%), which had significantly restricted their daily activities (51.7%) and had likely or very likely been caused by vertebral fractures (29.2% and 55.8%, respectively). Mean EuroQoL EQ-5D index value was 0.58±0.25 and VAS score 49.2±23.6. Non-vertebral fractures, back pain and multiple vertebral fractures were associated with lower HRQoL (EuroQoL-5D Index both p

【 授权许可】

Unknown