Clinical and Experimental Rheumatology | |
Diagnostic value of antibodies against mutated citrullinated vimentin for rheumatoid arthritis. | |
Emilio Besada1  Hans Nossent1  Cathrin Nikolaisen1  | |
关键词: Rheumatoid arthritis; anti-MCV; anti-CCP; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
OBJECTIVES: To compare the diagnostic efficiency of anti-MCV, anti-CCP2 and RF detection for patients with RA. METHODS: Cross-sectional study of patients with established rheumatic disease: rheumatoid arthritis (RA; n=75), psoriatic arthritis (PsA; n=25), 27 patients with ankylosing spondylitis (AS; n=27) and connective tissue disease (CTD; n=17). Anti-CCP2, anti-MCV and RF were detected by enzyme-linked immunosorbent assays on stored serum according to the manufacturer`s instructions. RESULTS: IgM-RF had the highest sensitivity, but the positive likelihood ratio is just 1.43. The detection of anti-MCV has a higher sensitivity for RA (76%), a specificity similar to anti-CCP2 (96%) resulting in the lowest negative likelihood ratio (0.25). Anti-MCV levels correlate well with anti-CCP2 levels (R=0.74; p
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020417138ZK.pdf | 393KB | download |