A new hypothesis of the possible mechanisms of gender differences in systemic lupus erythematosus

Clinical and Experimental Rheumatology

Akihiro Inui¹  Kazuhisa Nozawa¹  Yoshinari Takasaki¹  Ayako Yamaguchi¹  Maki Fujishiro¹  Kennji Takamori¹  Iwao Sekigawa¹  Mikiko Kawasaki¹  Hideoki Ogawa¹ 

关键词: Systemic lupus erythematosus;    gender bias;    oestrogens;    DNA microarrays;    human endogenous retroviruses;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

Numerous studies have suggested that sex hormones, especially oestrogens, can contribute to the onset and development of the disease activities of systemic lupus erythematosus (SLE), and this seems to be associated with the gender bias of SLE. In fact, there is significant evidence of the inductive effects of oestrogens on autoimmune-related immune responses, such as the production of antibodies, cytokines, and autoantigens including human endogenous retroviruses (HERV). The higher susceptibility to oestrogens in patients with SLE may be regulated by quantitative/qualitative abnormalities of oestrogen receptors (ERs) and different immune responsiveness to oestrogens in SLE patients in comparison to normal controls. In addition to previous findings, this report reviewed and discussed possible the mechanisms of gender bias of SLE based on results obtained by recently developed technologies such as DNA microarray methods.

【 授权许可】

Unknown